Short Courses

Please find below the list of short courses at ISC 2018. You can register to a morning and / or an afternoon course during the registration process.

Price per short course: EUR 80.00 (lunch included)

Sunday, September 23rd

09h00 - 12h00

  • #01: Introduction to Metabolomics Workflow
  • #02: Analytical characterization of protein biopharmaceuticals
  • #03: Flavors and Fragrances + Analytical Chemistry: an endless story

 

Short Course #01: Introduction to Metabolomics Workflow

Presenters:

  • Serge RUDAZ
  • Coral BARBAS

Short Course Summary:

The untargeted analysis of all the metabolites that change under a pathophysiological situation, or any wanted or unwanted action produced on a biological system, requires specific tools. In this short course, we will introduce the general concept of Metabolomics and it’s workflow. The main analytical platforms that are used, based on mass spectrometry will be presented, together with an introduction to the multivariate data analysis as well as Identification strategy of the instrumental signals to transform them into a name with a biological interpretation.

Short Course #02: Analytical characterization of protein biopharmaceuticals

Presenters:

  • Davy GUILLARME 
  • Koen SANDRA 

Short Course Summary:

The characterization of therapeutic proteins such as monoclonal antibodies (mAbs) represents a tremendous challenge. This short course will highlight the possibilities offered by all the different modes of chromatography (i.e. RPLC, SEC, IEX, HIC, HILIC) to rapidly and accurately characterize protein biopharmaceuticals (e.g., glycosylation, oxidation, deamidation, aggregation, lysine truncation…). The hyphenation of chromatographic approaches with mass spectrometry as well as the use of 2D-LC approaches will also be covered during the short course. Last but not least, the different levels of analysis of biopharmaceuticals will be discussed, including bottom-up analysis (2-5kDa), middle-up (25-100 kDa), and intact proteins analysis (150 kDa).

Short Course #03: Flavors and Fragrances + Analytical Chemistry: an endless story

Presenters:

  • Xavier FERNANDEZ
  • Frédéric BEGNAUD
  • Christophe PERES

Short Course Summary:

The palette of flavorists or perfumers is extremely rich and diverse, with more than 1000 compounds regularly used. These regroup a large variety of chemicals (synthetic, naturals, mixtures), which typically present high vapor pressure and significant hydrophobicity. Analytical chemistry has always played a key role in their discovery, and specific techniques had and still have to be invented to fit with the specificity of the molecules and applications. Quantification practices are today crucial, for instance to prove authenticity, answer regulatory concerns and correlate sensorial performance with exposure. This short course aims at presenting the state of the art analytical techniques used in F&F, and will mix theoretical approach and practical applications.

Sunday, September 23rd

14h00 - 17h00

  • #04: Development and Control of Robust HPLC Methods by Modeling
  • #05: Microextraction – The “green” sample preparation choice of next generation analytical chemists
  • #06: GC x GC: Fundamental principles, processes and applications

Short Course #04: Development and Control of Robust HPLC Methods by Modeling

Presenters:

  • Szabolcs FEKETE
  • Imre MOLNAR

Short Course Summary:

Method Modeling became nowadays an important tool in analytical sciences. Since the introduction of QbD in analytical work, trial & error type of method development became obsolete. Robust HPLC methods are today required by regulatory agencies and communication about details of robustness in HPLC methods need to be easily understandable for companies, which produce products in Pharma, Food and Biotech area.

With modeling, method development timescale can be shortened by a factor of 5-10.

The short course is dealing with column selection, discusses 2- and 3-dimensional retention modeling, gradient elution and robustness issues in HPLC method modeling. Besides of several industrial case studies about pharmaceutical applications for small and large molecules, such as monoclonal antibodies and their antibody-drug-conjugates (ADC’s), we will talk about aspects of regulatory work and principles of quality by design (QbD) in HPLC method development. Printed material will be provided. Laptops can be used for modeling.

Short Course #05: Microextraction – The “green” sample preparation choice of next generation analytical chemists

Presenters:

  • Stig PEDERSEN-BJERGAARD
  • Janusz PAWLISZYN

Short Course content:

  • Microextraction – A short introduction (15 min)
  • Solid-phase microextraction (SPME, 60-90 min)
    • Principles
    • Applications
    • Pros and cons
  • Liquid-phase microextraction (LPME, 60-90 min)
    • Principles
    • Applications
    • Pros and cons
  • Microextraction – Future directions and perspectives (15 min)

Short Course Summary:

Analytical microextraction technologies and methods have been developed for more than 25 years, and are gradually implemented in routine analytical applications. The workshop is devoted to the principles, applications, and routine implementation of solid-phase (SPME) and liquid-phase microextraction (LPME). Both SPME and LPME are superior to existing approaches in terms of (1) selectivity, (2) sample clean-up, (3) LC and GC compatibility, and (4) environmental sustainability. Also, the principles of SPME and LPME are perfectly suited for sensors and micro-scale on-site analytical measurements which are expected to be important in the future. Therefore, young analytical chemists should stay updated on analytical microextraction and follow the workshop.

Short Course #06: GC x GC: Fundamental principles, processes and applications

Presenter:

  • Philip MARRIOTT

Short Course Summary:

GCxGC is now acquiring the status of a mature method. But it is such a ‘disruptive technology’ that continuing explanation of its principles and training regarding its capabilities and use is valuable. This short course will introduce a selection of basic principles of GC´GC related to modulation processes, discuss performance and capabilities of GCxGC, and the course will be completed with selected applications.